He made the first experimental transplant in history of nerve cells taken from a human embryo, the starting point for modern stem cell research. Dr. Madrazo is one of the most-sought after neurosurgeons in North America for the treatment of Parkinson's disease. Dr. Madrazo is a pioneer in the area of brain transplants, and conducts research focused on studying the regeneration of the central nervous system. His laboratory is especially committed in the search for spinal cord regenerating mechanisms. He is a former presidente del comité de asesores de maestrías y doctorados en Medicina, Biomedicina y Sociomedicina [Chairman of the Advisory Committee of the Medicine, Biomedicine and Sociomedicine Master’s and Doctorate Degree programs] of the Universidad Nacional Autónoma de México (UNAM) [National Autonomous University of Mexico] – Instituto Mexicano del Seguro Social (IMSS) [Mexican Institute of Social Security]. He served as jefe de Neurocirugía del Centro Médico La Raza [chief of Neurosurgery at the La Raza
Medical Center]; director de Investigación Clínica en Neurología y Neurocirugía del Centro Médico Nacional Siglo XXI [director of Clinical Research on Neurology and Neurosurgery of the Siglo XXI National Medical Center], where he also served as jefe de Investigación y director del Hospital de Especialidades [chief of Research and director of the Specialties Hospital]. He is a former director general médico [Medical Director General] of the Instituto Mexicano del Seguro Social (IMSS) [Mexican Institute of Social Security]. Founder and scientific director of the Centro de Investigación CAMINA [CAMINA Research Center]. He is a member of the Consejo Consultivo de Ciencias de la Presidencia de la República (CCC) [Science Consulting Council of the President’s Office].

He is the recipient of the Premio Nacional de Ciencias y Artes [National Award for Science and Arts]; Premio “Miguel Otero”, del Consejo de Salubridad General [the “Miguel Otero” Prize of the General Health Council]; Premio “Académico Gonzalo Castañeda”, de la Academia Mexicana de Cirugía [the “Academic Gonzalo Castañeda” Prize, of the Mexican Surgery Academy]; Premio “Everardo Landa” de la Academia Nacional de Medicina [the “Everardo Landa” Prize of the National Academy of Medicine]. The Premio Nacional de Cirujía “Dr. Francisco Montes de Oca” [the “Dr. Francisco Montes de Oca” National Prize for Surgery]; Premio “Aida Weiss” [“Aida Weiss” Prize] from the Universidad Nacional Autónoma de México (UNAM) [National Autonomous University of Mexico]. President Miguel de la Madrid granted him a Medal of Recognition “for the international repercussion of his scientific work.” A Sesión Solemne de la Academia Nacional de Medicina [Solemn Session of the National Academy of Medicine] was held for the presentation and recognition of his work on the Treatment of Parkinso’n Disease. He received the “Nobel” Medal of the Karolinska Institute (Nobel Lecturer), in Stockholm, Sweden. He obtained the “José Ma. Morelos y Pavón” (Maximum Distinction) from the Universidad Autónoma de Morelos [Autonomous University of Morelos] and the State government.

Doctor Madrazo has 209 publications in refereed journals and has written 4 books. He has 2,369 citations in the "Science Citation Index". He is considered one of the twelve most often cited Mexican scientists in the 1981-1991 decade by the Life Sciences & Clinical Medicine Institute for Scientific Information (ISI). Finally, 32 countries have extended invitations for Dr. Madrazo to deliver one of his masterful lectures.